Your POI doesn't change, It's basically compared to your field of view on a higher power. As you in crease your magnification your mil-dots kinda become smaller in scale. I keep a cheat card with me that I printed out with the help of Chair Gun.
That way if I need to use a higher power I always know the mil dots.
And if you want the TECHY parts of it here..
On variable power scopes, the correct power for the Mildots to be accurate will depend on whether it's a First Focal Plane (FFP) scope or a Second Focal Plane (SFP) scope. On FFP scopes the appearance of the reticle changes with the power adjustment (the reticles don't change size, they're just magnified along with the rest of the view), so it is always accurate regardless of which power setting you're on. On a SFP scope, the reticles appears to be the same size through all the power settings so the mildots only subtends the correct size on one power setting, usually the highest power setting on the scope.
Here is a good place to read up on stuff related to Mil dots scopes
http://www.firearmstrainingandtactics.c ... agenumber=TJ